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KMID : 0545120030130020202
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Journal of Microbiology and Biotechnology
2003 Volume.13 No. 2 p.202 ~ p.206
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In Vitro Immunopotentiating Activity of Cellular Components of Lactococcus lactis ssp. lactis
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KIM, JI YEON
LEE, SEONGKYU/HACHIMURA, SATOSHI/KAMINOGAWA, SHUICHI/LEE, HYONG JOO
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Abstract
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To determine the effect of immunopotentiating activity of cellular components of Lactococcus lactis ssp. lactis, the immune function was analyzed in vitro using mice cells. When stimulated with mitogens, productions of IFN-γ, IL-12, TNF-α, and IL-6 were enhanced in spleen cells treated with cellular components, with IL-4 production being the highest in spleen cells treated with cytoplasm fraction. Without mitogen stimulation, the productions of IFN-γ and IL-12 were the highest in spleen cells treated with heat-killed whole cell. TNF-α and IL-6 productions were also high in spleen cells treated with all cellular components. Only heat-killed whole cell showed significant enhancement in natural killer cell activity. In peritoneal exudates cells, TNF-α productions was enhanced significantly by al cellular components of Lactococcus lactis ssp. lactis. These results indicate that the capable of stimulating immune cells to produce cytokines, and that both their cell walls and cytoplasm fraction contribute to these capacities.
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KEYWORD
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